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Abbreviation for Vascular Endothelial Growth Factor C. An under expression of this gene has been found and/or is believed to be responsible for Milroy's Disease (Milroy's Syndrome), Hereditary Lymphedema I.

An over expression of VEGF-C is indicative of lymphatic (cancer) metastasis.

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.

* Lymphedema

* Pathophysiology of Lymphedema

* Milroy's Syndrome

Lymphedema Genetics

Genetics, Research, Lymphangiogenesis, Angiogenesis

VEGF and its relationship to inflammatory mediators.

A novel VEGFR3 mutation causes Milroy disease.

Roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis

VEGF and PlGF promote adult vasculogenesis

PIGF antagonizes VEGF induced angiogenesis - tumor growth

Interaction of VEGF-C and VEGF-D with neuropilin receptors

Lymphatic hyperplasia, VEGF-C upregulation, MMP-9.

Milroy's Disease (lymphedema) and the VEGFR3 (FLT3)

The Formation of Lymphatic Vessels and Its Importance in the Setting of Malignancy

Lymphangiogenesis Breast Cancer the VEGF-C

Lymphangiogenesis and Gastric Cancer

Lymphangiogenesis in Head and Neck Cancer

Lymphangiogenesis and Kaposi's Sarcoma VEGF-C

Lymphangiogenesis and Melanoma

Lymphangiogenesis in Wound Healing

A model for gene therapy of human hereditary lymphedema

VEGFR-3 Ligands and Lymphangiogenesis (1)

VEGFR-3 Ligands and Lymphangiogenesis (2)

VEGFR-3 Ligands and Lymphangiogenesis (3)

Vascular Endothelial Growth Factor; VEGF

VEGF-D is the strongest angiogenic and lymphangiogenic effector

Inhibition of Lymphatic Regeneration by VEGFR3

VEGFR3 and Metastasis in Prostate Cancer

Radiogeneic Lymphangiogenesis in the Skin

Dose-dependent response of FGF-2 for lymphangiogenesis

Lymphangiogenesis Signalling Pathways in Human Disease

Lymphangiogenesis, inflammation and metastasis

Lymphatic endothelial cells, lymphangiogenesis, cell matrix

Influence of IFN- alpha and IFN- gamma on Lymphangiogenesis.

Expression of VEGF-C angiogenesis, lymphangiogenesis Cancer

VEGF-C gene therapy, Lymphangiogensis and Lymphedema

Molecular lymphangiogenesis: new players.

Genetics Glossary

glossary/vegf-c.txt · Last modified: 2012/10/16 14:40 (external edit)